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Articles in peer-reviewed journals


Allmann S, Morand P, Ebikeme C, Gales L, Biran M, Hubert J, Brennand A, Mazet M, Franconi JM, Michels PAM, Portais JC, Boshart M, Bringaud F.
Cytosolic NADPH Homeostasis in Glucose-starved Procyclic Trypanosoma brucei Relies on Malic Enzyme and the Pentose Phosphate Pathway Fed by Gluconeogenic Flux.
J Biol Chem. 2013, 288(25): 18494-18505:



Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhomme F, Bachmaier S, Kador M, Gossmann J, Dias FB, De Muylder G, Uzureau P, Magez S, Moser M, De Baetselier P, Van den Abbeele J, Beschin A, Boshart M, Pays E.
Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.
Science 337, 463-466.

Salmon D, Bachmaier S, Krumbholz C, Kador M, Gossmann JA, Uzureau P, Pays E and Boshart M.
Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4-like subfamily.
Molecular Microbiology 84, 225-242.

Millerioux Y, Morand P, Biran M, Mazet M, Moreau P, Wargnies M, Ebikeme C, Deramchia K, Gales L, Portais JC, et al.
ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma.
J Biol Chem 287, 17186-17197.


Bucerius F, Kador M, Boshart M, Janzen CJ.
Reliable quantification of cell cycle-dependent mRNA abundance using fluorescence-activated cell sorting in Trypanosoma brucei.
Mol Biochem Parasitol 175, 205-208.


Diskar M, Zenn HM, Kaupisch A, Kaufholz M, Brockmeyer S, Sohmen D, Berrera M, Zaccolo M, Boshart M, Herberg FW, Prinz A.
Regulation of cAMP-dependent protein kinases: the human Protein Kinase X (PrKX) reveals the role of the catalytic subunit {alpha}H-{alpha}I loop.
J Biol Chem. 2010 Sep 6. [Epub ahead of print]

Brenndörfer M, Boshart M.
Selection of reference genes for mRNA quantification in Trypanosoma brucei.
Mol Biochem Parasitol. 2010 Jul;172(1):52-5


Bringaud F, Ebikeme C, Boshart M.
Acetate and succinate production in amoebae, helminths, diplomonads, trichomonads and trypanosomatids: common and diverse metabolic strategies used by parasitic lower eukaryotes.
Parasitology. 2010 Aug;137(9):1315-31

Rivière L, Moreau P, Allmann S, Hahn M, Biran M, Plazolles N, Franconi JM, Boshart M, Bringaud F.
Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes.
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12694-9.


Engstler M, Pfohl T, Herminghaus S, Boshart M, Wiegertjes G, Heddergott N, Overath P.
Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes.
Cell. 2007 Nov 2;131(3):505-15

Hammarton TC, Kramer S, Tetley L, Boshart M, Mottram JC.
Trypanosoma brucei Polo-like kinase is essential for basal body duplication, kDNA segregation and cytokinesis.
Mol Microbiol. 2007 Sep;65(5):1229-48

Kramer S, Klöckner T, Selmayr M, Boshart M.
Interstrain sequence comparison, transcript map and clonal genomic rearrangement of a 28 kb locus on chromosome 9 of Trypanosoma brucei.
Mol Biochem Parasitol. 2007 Jan;151(1):129-32


Coustou V, Besteiro S, Rivière L, Biran M, Biteau N, Franconi JM, Boshart M, Baltz T, Bringaud F.
A mitochondrial NADH-dependent fumarate reductase involved in the production of succinate excreted by procyclic Trypanosoma brucei.
J Biol Chem. 2005 Apr 29;280(17):16559-70


Engstler M, Boshart M.
Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei.
Genes Dev. 2004 Nov 15;18(22):2798-811

Rivière L, van Weelden SW, Glass P, Vegh P, Coustou V, Biran M, van Hellemond JJ, Bringaud F, Tielens AG, Boshart M.
Acetyl:succinate CoA-transferase in procyclic Trypanosoma brucei. Gene identification and role in carbohydrate metabolism.
J Biol Chem. 2004 Oct 29;279(44):45337-46

Engstler M, Thilo L, Weise F, Grünfelder CG, Schwarz H, Boshart M, Overath P.
Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei.
J Cell Sci. 2004 Mar 1;117(Pt 7):1105-15
Erratum in: J Cell Sci. 2004 Jul 15;117(Pt 16):3703

McCulloch R, Vassella E, Burton P, Boshart M, Barry JD.
Transformation of monomorphic and pleomorphic Trypanosoma brucei.
Methods Mol Biol. 2004;262:53-86

Kunz S, Kloeckner T, Essen LO, Seebeck T, Boshart M.
TbPDE1, a novel class I phosphodiesterase of Trypanosoma brucei.
Eur J Biochem. 2004 Feb;271(3):637-47


Heilbronn R, Engstler M, Weger S, Krahn A, Schetter C, Boshart M.
ssDNA-dependent colocalization of adeno-associated virus Rep and herpes simplex virus ICP8 in nuclear replication domains.
Nucleic Acids Res. 2003 Nov 1;31(21):6206-13

Hammarton TC, Clark J, Douglas F, Boshart M, Mottram JC.
Stage-specific differences in cell cycle control in Trypanosoma brucei revealed by RNA interference of a mitotic cyclin.
J Biol Chem. 2003 Jun 20;278(25):22877-86

van Weelden SW, Fast B, Vogt A, van der Meer P, Saas J, van Hellemond JJ, Tielens AG, Boshart M.
Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation.
J Biol Chem. 2003 Apr 11;278(15):12854-63


Grünfelder CG, Engstler M, Weise F, Schwarz H, Stierhof YD, Boshart M, Overath P.
Accumulation of a GPI-anchored protein at the cell surface requires sorting at multiple intracellular levels.
Traffic. 2002 Aug;3(8):547-59


Vassella E, Krämer R, Turner CM, Wankell M, Modes C, van den Bogaard M, Boshart M.
Deletion of a novel protein kinase with PX and FYVE-related domains increases the rate of differentiation of Trypanosoma brucei.
Mol Microbiol. 2001 Jul;41(1):33-46

2000 and earlier

Saas J, Ziegelbauer K, von Haeseler A, Fast B, Boshart M.
A developmentally regulated aconitase related to iron-regulatory protein-1 is localized in the cytoplasm and in the mitochondrion of Trypanosoma brucei.
J Biol Chem. 2000 Jan 28;275(4):2745-55

Fast B, Kremp K, Boshart M, Steverding D.
Iron-dependent regulation of transferrin receptor expression in Trypanosoma brucei.
Biochem J. 1999 Sep 15;342 Pt 3:691-6

Clayton C, Adams M, Almeida R, Baltz T, Barrett M, Bastien P, Belli S, Beverley S, Biteau N, Blackwell J, Blaineau C, Boshart M, Bringaud F, Cross G, Cruz A, Degrave W, Donelson J, El-Sayed N, Fu G, Ersfeld K, Gibson W, Gull K, Ivens A, Kelly J, Vanhamme L, et al.
Genetic nomenclature for Trypanosoma and Leishmania.
Mol Biochem Parasitol. 1998 Nov 30;97(1-2):221-4

Vassella E, Straesser K, Boshart M.
A mitochondrion-specific dye for multicolour fluorescent imaging of Trypanosoma brucei.
Mol Biochem Parasitol. 1997 Dec 1;90(1):381-5

Reuner B, Vassella E, Yutzy B, Boshart M.
Cell density triggers slender to stumpy differentiation of Trypanosoma brucei bloodstream forms in culture.
Mol Biochem Parasitol. 1997 Dec 1;90(1):269-80

Vassella E, Reuner B, Yutzy B, Boshart M.
Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway.
J Cell Sci. 1997 Nov;110 ( Pt 21):2661-71

Lücke S, Klöckner T, Palfi Z, Boshart M, Bindereif A.
Trans mRNA splicing in trypanosomes: cloning and analysis of a PRP8-homologous gene from Trypanosoma brucei provides evidence for a U5-analogous RNP.
EMBO J. 1997 Jul 16;16(14):4433-40

Vassella E, Boshart M.
High molecular mass agarose matrix supports growth of bloodstream forms of pleomorphic Trypanosoma brucei strains in axenic culture.
Mol Biochem Parasitol. 1996 Nov 12;82(1):91-105

Faust DM, Boshart M, Imaizumi-Scherrer T, Schütz G, Weiss MC.
Constancy of expression of the protein kinase A regulatory subunit R1 alpha in hepatoma cell lines of different phenotypes.
Cell Growth Differ. 1994 Jan;5(1):47-53

Schmid W, Nitsch D, Boshart M, Schütz G.
Role of cyclic AMP in the control of cell-specific gene expression.
Trends Endocrinol Metab. 1993 Aug;4(6):204-9

Boshart M, Nitsch D, Schütz G.
Extinction of gene expression in somatic cell hybrids - a reflection of important regulatory mechanisms?
Trends Genet. 1993 Jul;9(7):240-5

Nitsch D, Boshart M, Schütz G.
Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements.
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5479-83

Nitsch D, Boshart M, Schütz G.
Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcriptional activators.
Genes Dev. 1993 Feb;7(2):308-19

Nichols M, Weih F, Schmid W, DeVack C, Kowenz-Leutz E, Luckow B, Boshart M, Schütz G.
Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.
EMBO J. 1992 Sep;11(9):3337-46

Ruppert S, Cole TJ, Boshart M, Schmid E, Schütz G.
Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes.
EMBO J. 1992 Apr;11(4):1503-12

Jansen-Dürr P, Boshart M, Lupp B, Bosserhoff A, Frank RW, Schütz G.
The rat poly pyrimidine tract binding protein (PTB) interacts with a single-stranded DNA motif in a liver-specific enhancer.
Nucleic Acids Res. 1992 Mar 25;20(6):1243-9

Boshart M, Klüppel M, Schmidt A, Schütz G, Luckow B.
Reporter constructs with low background activity utilizing the cat gene.
Gene. 1992 Jan 2;110(1):129-30

Boshart M, Weih F, Nichols M, Schütz G.
The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase.
Cell. 1991 Sep 6;66(5):849-59

Weih F, Stewart AF, Boshart M, Nitsch D, Schütz G.
In vivo monitoring of a cAMP-stimulated DNA-binding activity.
Genes Dev. 1990 Aug;4(8):1437-49

Nitsch D, Stewart AF, Boshart M, Mestril R, Weih F, Schütz G.
Chromatin structures of the rat tyrosine aminotransferase gene relate to the function of its cis-acting elements.
Mol Cell Biol. 1990 Jul;10(7):3334-42

Ruppert S, Boshart M, Bosch FX, Schmid W, Fournier RE, Schütz G.
Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes.
Cell. 1990 Jun 1;61(5):895-904

Boshart M, Weih F, Schmidt A, Fournier RE, Schütz G.
A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1.
Cell. 1990 Jun 1;61(5):905-16

Strähle U, Boshart M, Klock G, Stewart F, Schütz G.
Glucocorticoid- and progesterone-specific effects are determined by differential expression of the respective hormone receptors.
Nature. 1989 Jun 22;339(6226):629-32

Jantzen HM, Strähle U, Gloss B, Stewart F, Schmid W, Boshart M, Miksicek R, Schütz G.
Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene.
Cell. 1987 Apr 10;49(1):29-38

Boshart M, zur Hausen H.
Human papillomaviruses in Buschke-Löwenstein tumors: physical state of the DNA and identification of a tandem duplication in the noncoding region of a human papillomavirus 6 subtype.
J Virol. 1986 Jun;58(3):963-6

Schütz G, Schmid W, Jantzen M, Danesch U, Gloss B, Strähle U, Becker P, Boshart M.
Molecular basis for the hormonal regulation of the tyrosine aminotransferase and tryptophan oxygenase genes.
Ann N Y Acad Sci. 1986;478:93-100

Boshart M, Weber F, Jahn G, Dorsch-Häsler K, Fleckenstein B, Schaffner W.
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus.
Cell. 1985 Jun;41(2):521-30

Gissmann L, Boshart M, Dürst M, Ikenberg H, Wagner D, zur Hausen H.
Presence of human papillomavirus in genital tumors.
J Invest Dermatol. 1984 Jul;83(1 Suppl):26s-28s

Boshart M, Gissmann L, Ikenberg H, Kleinheinz A, Scheurlen W, zur Hausen H.
A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.
EMBO J. 1984 May;3(5):1151-7